article,
aside,
details,
figcaption,
figure,
footer,
header,
hgroup,
main,
nav,
section,
summary {
    display: block;
}
audio,
canvas,
video {
    display: inline-block;
}
audio:not([controls]) {
    display: none;
    height: 0;
}
[hidden] {
    display: none;
}
html {
    font-family: sans-serif; 
    -webkit-text-size-adjust: 100%; 
    -ms-text-size-adjust: 100%; 
}
body {
    margin: 0;
}
a:focus {
    outline: thin dotted;
}
a:active,
a:hover {
    outline: 0;
}
h1 {
    font-size: 2em;
    margin: 0.67em 0;
}
abbr[title] {
    border-bottom: 1px dotted;
}
b,
strong {
    font-weight: bold;
}
dfn {
    font-style: italic;
}
hr {
    -moz-box-sizing: content-box;
    box-sizing: content-box;
    height: 0;
}
mark {
    background: #ff0;
    color: #000;
}
code,
kbd,
pre,
samp {
    font-family: monospace, serif;
    font-size: 1em;
}
pre {
    white-space: pre-wrap;
}
q {
    quotes: "\201C" "\201D" "\2018" "\2019";
}
small {
    font-size: 80%;
}
sub,
sup {
    font-size: 75%;
    line-height: 0;
    position: relative;
    vertical-align: baseline;
}
sup {
    top: -0.5em;
}
sub {
    bottom: -0.25em;
}
img {
    border: 0;
}
svg:not(:root) {
    overflow: hidden;
}
figure {
    margin: 0;
}
fieldset {
    border: 1px solid #c0c0c0;
    margin: 0 2px;
    padding: 0.35em 0.625em 0.75em;
}
legend {
    border: 0; 
    padding: 0; 
}
button,
input,
select,
textarea {
    font-family: inherit; 
    font-size: 100%; 
    margin: 0; 
}
button,
input {
    line-height: normal;
}
button,
select {
    text-transform: none;
}
button,
html input[type="button"], 
input[type="reset"],
input[type="submit"] {
    -webkit-appearance: button; 
    cursor: pointer; 
}
button[disabled],
html input[disabled] {
    cursor: default;
}
input[type="checkbox"],
input[type="radio"] {
    box-sizing: border-box; 
    padding: 0; 
}
input[type="search"] {
    -webkit-appearance: textfield; 
    -moz-box-sizing: content-box;
    -webkit-box-sizing: content-box; 
    box-sizing: content-box;
}
input[type="search"]::-webkit-search-cancel-button,
input[type="search"]::-webkit-search-decoration {
    -webkit-appearance: none;
}
button::-moz-focus-inner,
input::-moz-focus-inner {
    border: 0;
    padding: 0;
}
textarea {
    overflow: auto; 
    vertical-align: top; 
}
table {
    border-collapse: collapse;
    border-spacing: 0;
}
.grid{ min-width:800px; max-width:1200px; width:100%; clear:both; margin:0 auto; text-align:left;overflow:hidden }
.col { margin-right: 1%; float: left; background-color: #fff; overflow:hidden; }
.last { *zoom:1; *margin-right:0; _margin-right:-6px;  }
.col.last {float:right;}
.one_col { width: 7.3333%; }
.two_col { width: 15.6664%; }
.three_col { width: 23.9999%; }
.four_col { width: 32.3333%; }
.five_col { width: 40.6666%; }
.six_col { width: 48.9999% }
.seven_col { width: 57.3333%; }
.eight_col { width: 65.6666%; }
.nine_col { width: 73.9999%; }
.ten_col { width: 82.3333%; }
.eleven_col { width: 90.6666%; }
.twelve_col { width: 98.9999%; }
@media screen and (max-width: 1200px) {
	body > .grid > .twelve_col { width: 100%; }
}
body{font:62.5%/1.3846 arial,helvetica,clean,sans-serif;background-color:#ccc;margin:0}
.grid{font-size: 1.3em}
img{border:0}
abbr,acronym{cursor:help;border-bottom:1px dotted #000;}
blockquote{margin:1.3846em 1em;}
p,table,pre,fieldset,dl{margin: 0.6923em 0;}
ol,ul{margin: 0.6923em 1em 0.6923em inherit}
dl dd{margin-left:1em;}
table{border-collapse:collapse;margin:1.3846em 0;}
thead{border-bottom:1px solid #eee;}
tfoot{border-top:1px solid #eee;}
th{text-align:center;background-color:#f0f0f0;}
th,td{padding:0.2em;border:1px solid #ddd;}
caption{margin-bottom:.5em;text-align:center;}
fieldset {border: 0;}
button{cursor:pointer;}
input,button,textarea{margin:2px;}
input[type="checkbox"] {margin: 3px 3px 3px 4px;}
textarea {font-family: monospace; font-size: 1.2296em; *font-size:1em; vertical-align:baseline;}
h1,.h1{font-size: 1.3846em; line-height:1.5; margin:1em 0 .5em; } 
h2,.h2{font-size: 1.2307em; line-height:1.125; margin:1.125em 0 .5625em;} 
h3,.h3{font-size: 1.0769em; line-height:1.2857; margin:1.2856em 0 .6428em; } 
h4,h5,h6,h3.inline{font-size: 1em; margin:1.3846em 0 .6923em; } 
h5,.h5{font-style:italic;font-weight:normal;}
h6, .h6 {font-weight: normal;}
h4,.h4{color:#59331f;}
h3,.h3{color:#724128;}
h2,.h2{color:#985735;}
h1,.h1{color:#000;}
h3.inline,h4.inline,h5.inline,h6.inline{display:inline;float:left;margin:0 0 -0.125em;padding-right:.3em}
.whole_rhythm {margin: 1.3846em 0} 
.half_rhythm {margin: .6923em 0} 
.no_top_margin{margin-top:0}
.no_bottom_margin{margin-bottom:0}
.no_margin{margin:0}
.content a{color:#2f4a8b}
.content a:hover,.content a:active{color:#985735}
.content a:visited{color:#642a8f}
.inline_list,.inline_list_right{list-style-type:none;margin:0;padding:0}
.inline_list li{display:inline;margin-right:.3em}     
.inline_list_right li{display:inline;margin-left:.4em;}
.column_list{list-style-type:none;margin:0;padding:0}
.column_list li{float:left;width:8em}
.offscreen{text-indent:-9999px}
.offscreen_noflow{float:left;text-indent:-9999em;_display:block;margin:0;padding:0;height:0;}
.left{float:left}
.right{float:right}
.align_right{text-align:right}
.hidden{display:none}
.nowrap{white-space:nowrap}
.noborder{border:0}
body .no_max_width{max-width:none;overflow:auto}
.inline_block{display:-moz-inline-box;display:inline-block;*display:inline;zoom:1;}
.clearfix:before,.clearfix:after{content:"";display:table}.clearfix:after{clear:both}.clearfix{zoom:1}
.small,sup,sub{font-size:.8461em; line-height: 1.6363em;} 
.small sup,.small sub{font-size:1em}
sup,sub{position:relative;vertical-align:baseline;}
sup{top:-.5em}
sub{top:.25em}
.shadow {-webkit-box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3);-moz-box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3);box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,.3)}
.iconblock{overflow:hidden}
.icnblk_img{text-decoration:none;float:left;margin-right:1em;cursor:pointer}
.icnblk_img_right { float: right; margin-right: 0; margin-left: 1em;}
.icnblk_cntnt{display:table-cell;vertical-align:top;*zoom:1}
.icnblk_cntnt h1,.icnblk_cntnt h2,.icnblk_cntnt h3,.icnblk_cntnt h4{margin:0 0 .6923em}
.tgt_light{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2846531) no-repeat 100% -1%;padding-right:17px;margin-right: 3px}
.tgt_light:active{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2846531) no-repeat 100% 12%}
.tgt_dark{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2846531) no-repeat 100% 43.5%;padding-right:17px;margin-right:3px}
.tgt_dark:active{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2846531) no-repeat 100% 25%}
.tgt_light_up{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2846531) no-repeat 100% 56%;padding-right:17px;margin-right:3px}
.tgt_light_up:active{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2846531) no-repeat 100% 69%}
.tgt_dark_up{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2846531) no-repeat 100% 100%;padding-right:17px;margin-right:3px}
.tgt_dark_up:active{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2846531) no-repeat 100% 83%}
.tabPopper{top:0;left:0;display:none;background-color:#fff;padding:.2em;margin-top:3px;*padding-bottom:1em;box-shadow:.4em .4em .5em #999;-webkit-box-shadow:.4em .4em .5em #999;-moz-box-shadow:.4em .4em .5em #999;border:1px solid #ccc;border-bottom:1px solid #666\0;border-right:1px solid #666\0;}
.tabPopperCover{position:absolute;top:0px;left:0px;height:1px;background-color:#FFA600;overflow:hidden}
.tabPopper fieldset{border:0;padding:0;margin:4px 10px}
.tabPopper fieldset ul,.tabPopper fieldset dl{border-top:1px solid #ddd;padding-top:3px}
.tabPopper fieldset dl{margin:0 0 6px 0}
.tabPopper fieldset input{position:relative;top:1px}
#maincontent .content{ padding:0 0 2em 1.231em; }
#maincontent .content .content { padding-left: 0; }
.title_and_pager{margin:.9em 0 1.3em}
.results_settings,.title_and_pager,.rprt{zoom:1}
.nlm{font-size:.692em;line-height:1.2;margin-top:.2em}
.nlm a{color:#555}
.pmlogo{background:transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2318832) no-repeat scroll left top;display:block;height:32px;width:110px;text-indent:-9999px}
noscript p.nojs {
	background: #ffb url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/67327) no-repeat 5px center;
	padding: 4px;
	padding-left: 28px;
	margin:0;	
}
.header{background:#d5d5d5 url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/2375536) repeat-x scroll left bottom; position: relative;margin-bottom: 1.231em;z-index:20 }
.header a{text-decoration:none}
.header a:hover{text-decoration:underline}
.search{margin:0 0 0 13.539em; padding:1.2em 0 .7em}
.search_form{*zoom:1}
.search_form select,.search_form .ui-ncbiclearbutton-wrap,.search_form button{margin-right:.2em;font-family:arial,helvetica,sans-serif;}
.search_form select{font-size: 1.077em; width:8.5em;margin-right:.3em;*vertical-align: middle; position: relative; bottom: 1px;}
.search_form select optgroup {font-style: normal; color: #555; padding-left: 0.2em;} 
.search_form select optgroup option {color: #000}
.search_form input{font-size: 1.1543em; width:48%;display:inline-block;_width:100%}
.search_form div.nowrap {*height: 100%; }
.search_form button.nowrap {*vertical-align: middle; }
.search_form div.nowrap div.nowrap {*height: 100%; *vertical-align: middle; }
.search_form .nowrap{display:inline;*zoom:1}
.searchlinks{margin:.2em 0 0 9.6em;_zoom:1}
.searchlinks li{margin-right:1.2em;zoom:1}
.searchlinks .help{position:absolute;right:1em;margin-right:0;_margin-top:-.1em}
.searchlinks .hidden{display:none}
.searchlinks .visible{display:inline}
.search_form .wrap{position:relative;display:inline;_width:70%}
#cl{position:absolute;right:8px;top:-3px;top:-12px\9;*top:5px}
.search_form button{border:0 none;cursor:pointer;overflow:visible;width:auto;background-color:#ddd;padding:.2em .4em;*padding:.2em .6em;_padding:.2em .4em;margin:0 .2em;*margin:0 .3em;*height:2em; -moz-border-radius:5px;-webkit-border-radius:5px;border-radius:5px;text-shadow:.1em .1em .1em rgba(0,0,0,.5);-moz-box-shadow:.1em .1em .1em rgba(0,0,0,.5);-webkit-box-shadow:.1em .1em .1em rgba(0,0,0,.5);box-shadow:.1em .1em .1em rgba(0,0,0,.5)}
.search_form button.button_search{background-color:#47a;font-weight:bold;color:#fff;*margin-left:.5em;font-size:inherit;}
.search_form button.button_search:active{background-color:#4c96df}
.search_form button.button_preview{background-color:#A64D48;font-weight:bold;color:#fff}
.search_form button.button_preview:active{background-color:#F27069}
.search_form input:focus{-moz-box-shadow:0 0 .3em rgba(211,186,44,.8)}
.search_form .ui-ncbiclearbutton-wrap { width: 64%; *display: inline; border:1px solid #999; }
.search_form .ui-ncbiclearbutton-wrap input { width: 100%; *width: 50%; }
.search_form .ui-ncbiclearbutton-wrap a.reset { margin-left: 0; top: 50%; margin-top: -7px; }
.rss_icon{position:relative;top:3px;margin-right:.3em}
.rss_menu{z-index:1001;display:none;}
.rss_menu legend{font-weight:bold;margin:2px 0 0 3px}
.rss_menu ul{margin:0;padding:0;list-style-type:none;padding-top:5px}
.rss_menu ul li{margin-bottom:.4em}
.rss_menu span,.rss_menu label{margin-right:.5em}
.rss_menu ul input{top:0}
.rss_menu dd{margin-left:0;margin-bottom:1em}
.rss_menu #rss_name{width:15em}
.rss_menu button{margin-top:.5em}
.rss_menu label{display:block}
.db_logo{background:transparent url() no-repeat scroll left top;display:block;height:36px;width:100px;text-indent:-9999px}
.res_logo{width:11.539em;left:1.231em;padding-top:.4em;position:absolute}
.res_logo h1{font-weight:normal;margin:0}
.long{padding:.5em 0}
.long h1{line-height:1.15}
.res_logo h1 a{color:#333;display:block;padding:.3em 0;text-shadow:1px 1px 1px rgba(240,240,240,.9)}
.res_tagline{display:none}
.res_logo h1 a,.res_logo h1 a:hover,.res_logo h1 a:visited{text-decoration:none}
h1.img_logo{margin:0}
h1.img_logo a{padding:0}
.rprt {
	overflow: hidden;
	_overflow: none;
	margin: 0.5em 0 1.5em 0;
	padding: 0; 
	*margin-bottom: 0.9em;
	zoom: 1;
	display: block;
	clear: both;
	min-height: 40px;
	height: auto !important;
	height: 40px; }
.rprt .rprtnum {
	display: inline;
	float: left;
	overflow: visible; }
.rprt .rprtnum input {
	display: block;
	float: none;
	margin-left: 0; }
.rprt .rprtnum span {
	display: block;
	clear: both;
	margin-right: 5px;
	margin-left: 1px; 
	*margin-left: 4px; }
.rprt .rslt { margin-left: 28px; *height: 1%; *margin-left: 0; }
.rprt .rsltimg { float: left; }
.rprt .rsltimg_right { float: right; margin-right: 0; margin-left: 1em;}
.rprt .rsltimg img {
	width: 100px;
	border: #666 solid 1px;
	padding: 1px; }
.rprt .rsltimg + .rsltcont { padding-left: 120px; }
.rprt .rsltimg_right + .rsltcont { padding-left: 0; }
.rprt .title {
	font-size: 1.108em;
	margin: 0; }
.rprt .title a { color: #2222cc; }
.rprt .title a:visited { color: #642a8f; }
.rprt .supp { margin: .1425em 0; }
.rprt .supp p, .rprt .supp dl, .rprt .supp dt, .rprt .supp dd { margin: 0; }
.rprt .supp .desc {
	font-size: 1.077em;
	display: block; }
.rprt .supp .details {
	font-size: 0.923em;
	display: block; }
.rprt dl{margin:0}
.rprt dl dt, .rprt dl dd {
	display: inline;
	padding: 0;
	margin: 0; }
.rprt dl dt { margin-left: .5em !important; }
.rprt dl dt:first-child { margin-left: 0 !important; }
.rprt dl.details { _margin-left: -.5em !important; }
.rprt dl dd, .rprt dl dt { white-space: nowrap; }
.rprt dl.lefty{display:block}
.rprt dl.lefty dt{width:10em;display:table-cell}
.rprt dl.lefty dd{display:table-cell}
.rprt dl.butterfly{display: block;margin:0;clear:both}
.rprt dl.butterfly dt{width: 10em; float: left; clear: left; text-align: right; margin-right: 10px;  }
.rprt dl.butterfly dd{margin: 0 0 0 10em; clear: right; }
	
.rprt .aux { font-size: 0.923em; }
.rprt .aux .status_icon, .rprt .aux .links a { white-space: nowrap; }
.rprt .aux, .rprt .aux p, .rprt .aux dl {
	margin-top: 0;
	margin-bottom: 0;
	line-height: 1.4em;  }
.rprt .aux .resc { color: #575757; }
.rprt .aux .status_icon {
	color: #985735;
	font-weight: bold; }
.rprt .aux .src {
	margin-right: 15px;
	display: inline; }
.rprt .aux .rprtid {
	color: #575757;
	display: inline;
	margin-right: 15px; }
.rprt .aux .links a {
	text-decoration: underline;
	cursor: pointer;
	margin-right: 15px;
	color: #6666AA;
	white-space: nowrap; }
.rprt .aux .links .in_clip {
	margin-right: .5em;
	color: #D2692B;
	white-space: nowrap; }
.rprt .aux .links .rem_clip {
	margin-right: .5em;
	color: #D2692B;
	text-decoration: none;
	border-bottom: 1px dotted #D2692B;
	white-space: nowrap; }
.rprt .dblinks {
	margin-top: 0em;
	margin-bottom: 0em;
	line-height: 1.334em; }
.rprt .dblinks a {
	text-decoration: none;
	cursor: pointer;
	white-space: nowrap;
	color: #6666AA; }
.rprt .dblinks a:hover { text-decoration: underline; }
.rprt p.title a {
	_position: relative;
	_left: -.15em; }
.rprt-button { float: right }
.rprt-button span { margin: 0.231em 0.462em 0.462em -0.462em }
.rprt-supplinks { padding: 0.461em 0 }
.rprt-supplinks h5 { margin: 0.231em 0 }
.rprt-supplinks p { margin-top: 0 }
.rprt-supplinks .rprt-seeall {
    text-align: right;
    font-size: 0.846em;
    margin: 0; }
.rprt-separator {
    border-style: none;
    font-size: 0;
    height: 1px;
    margin: -1px 0;
    opacity: 0;
    position: relative; }
.new-pubmed-banner-ad{ 
    background-image: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/4188105); 
    background-size: 100% auto;
    background-attachment: scroll;
    background-repeat: no-repeat; 
    text-indent: 100%;
    white-space: nowrap;
    overflow: hidden;
    display: block;
    padding-top: 10%;
    margin-bottom: 1%; 
}
.ad_banner { padding-left: 1.231em; }
.ncbi_carousel{ background-color: #f2f5f8;
    border: 1px solid #9bb0c8;
    margin: 1em 0;
    overflow: hidden;
    padding-top: 0.1em;
    position: relative;
} 
.ncbi_carousel .nc_header{margin:auto auto 5px 5px;}
.ncbi_carousel .nc_content{position:relative;
    min-width: 300px;
    overflow: hidden;
    padding-top: 0.1em;
    height:200px;
}
.ncbi_carousel .nc_item {position:absolute;top:2px;border: 1px solid #14376c;}
.ncbi_carousel .nc_arrow {
    border-bottom: medium none;
    height: 250px;
    width: 20px;
    position: absolute;
    top: 20px;
    z-index:100;
    opacity: 0.4;
}
.ncbi_carousel .nc_arrow_left {
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/252363) no-repeat scroll left center transparent;
    left: 0;
}
.ncbi_carousel .nc_arrow_right {
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/252362) no-repeat scroll right center transparent;
    right: 0;
}
.ncbi_carousel .nc_arrow_inactive {
    cursor: default;
    opacity: 0.1;
}
.ncbi_carousel .nc_arrow_highlight{
    opacity: 1;
}
.ncbi_carousel .nc_toggler{
    position:absolute;
    right:0;
    background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/32197) no-repeat top right;
    padding-right:20px;
    text-decoration: none;
}
.ncbi_carousel .nc_toggler_open{
    
}
.ncbi_carousel .nc_toggler_closed{
    background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/32197) no-repeat bottom right;
}
.abstract.rprt { padding-bottom: 0.5em; }
.abstract h1 { font-size: 1.4em; font-weight: bold; line-height: 1.25em; margin: .5em 0; }
.abstract h1 a { font-weight: bold; } 
.abstract p { margin: .5em 0; }
.abstract a { color: #333; border-bottom: 0; text-decoration: underline; }
.abstract a:hover { color: #2222CC; border-bottom: 0; }
.abstract a:visited { color: #606; border-bottom: 0; }
.abstract a.jig-ncbitoggler, .abstract a.jig-ncbitoggler:hover { text-decoration: none !important; }
.abstract a.ui-ncbitoggler, .abstract a.ui-ncbitoggler-open { padding-left: 1.75em; }
.abstract a.ui-ncbitoggler span.ui-icon-triangle-1-e { background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/29039) no-repeat left -30px; }
.abstract a.ui-ncbitoggler-open span.ui-icon-triangle-1-s  { background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/29039) no-repeat left 0; }
.abstract a.ui-ncbitoggler {  }
.abstract a.ui-ncbitoggler:hover { color: #777; }
.abstract .err h3, .morecit h4 { margin: .5em 0 0 0 !important; display: block; color: #000; }
.abstract .err ul { margin: 0 0 .5em; list-style-type: none; padding:0; }
.abstract .err li { display: block; }
.abstract .err .comments a { color: #14376C; text-decoration: none; }
.abstract .err .comments .source { padding-left: 0.3em; color: #777777; }
.abstract .err .comments em.author { font-size: 0.8465em; line-height: 1.3em; display: block; margin-bottom: -0.3em; margin-top: 0.5em; }
.abstract .err .comments em.cit { font-size: 0.8465em; line-height: 1.3em; display: block; margin-bottom: -0.3em; margin-top: 0.5em; }
.abstract .err { margin: 1.1em auto 0; }
.abstract .abstr { line-height: 1.538em; }
.abstract .abstr h3, .abstract .sections h3 {color:#985735; font-weight:bold; margin: 0; ;}
.abstract .sections ul {list-style:none;padding:0px;margin-top:0px;margin-left:0;}
.abstract .sections h4 {margin:0;}
.abstract .sections ul a.ui-ncbitoggler, .abstract .sections ul a.ui-ncbitoggler-open { padding-left: .85em; }
.abstract .sections ul .ui-ncbitoggler-master-text { padding-left:0.3em; }
.abstract .sections ul a.ui-ncbitoggler:hover, .abstract .sections ul a.ui-ncbitoggler-open:hover { color: #777; border-bottom: none; }
.abstract .abstr h4,.abstract .keywords h4 { color: #000; font-weight: bold; text-transform: uppercase; float: left; margin: 0 .25em 0 0; }
.abstract .abstr p{ margin-top: 0; margin-bottom:0.5em; font-size: 1.04em; }
.abstract .abstr .copyright { font-size: 0.93em;}
.abstract .afflist dt { float: left; width: 30px; margin: 0 !important; padding: 0 0 0.2em;; display:block;}
.abstract .afflist dd { margin-left: 30px; padding: 0 0 0.2em; display: block;  white-space: normal; }
.abstract .aux { font-size: inherit; }
.abstract .aux, .abstract .abstr, .abstract .sections,.abstract .keywords { margin:  1.2em auto auto; }
.abstract .aux .in_clip { color: #D2692B; white-space: nowrap; }
.abstract .aux .status_icon { margin: 0 15px 0 0; color: #985735; font-weight: bold; }
.abstract .aux a.status_icon {text-decoration: none; cursor: pointer;}
.abstract .aux .resc.status { padding-top: 0.5em; }
.abstract .aux .rprtid dt { margin-left: 10px !important; }
.abstract .aux .rprtid dt:first-child { margin-left: 0 !important; }
.abstract .aux .rprtid a:visited { color: #333; }
.abstract .auths,.abstract .keywords { font-size: 0.923em; }
.abstract .cit, .abstract .aff, .abstract .rprtid { font-size: 0.8465em; }
.abstract .cit { line-height: 1.45em; }
.abstract .aff { line-height: 1.0915em; }
.abstract .pmcid { color:#666666; margin-left: 15px; }
.abstract .pmid, .abstract .pmcid, .abstract .status_icon { white-space: nowrap; } 
.abstract .versions {margin-right: 15px; }
.abstract .keywords {margin-top:1.8em;}
.abstract .keywords h4 { margin: 0 .35em 0 0; }
.abstract .links a.status_ra { color:#6666AA; cursor: pointer; margin-right:15px; }
.abstract .links a.status_ra:hover { color:#6666AA; }
.abstract .links a.status_ra:visited { color:#6666AA; }
.abstract .retracted-alert {margin-bottom: 2em; margin-top: 0; padding: 1em; background-color: #f9dede; 
    background-size: 3.6em auto; background-position: 0.8em 1.6em; background-repeat: no-repeat;
    background-image: url("https://www.ncbi.nlm.nih.gov/labs/static/django_uswds/uswds/img/alerts/error.svg");}
.abstract .retracted-alert-body { display: table-cell; padding-left: 4em; vertical-align: top; }
.abstract .retracted-alert-heading { margin-top: 0.3em; margin-bottom: 0.3em; font-size: 2em; 
    clear: both; font-family: "Merriweather","Georgia","Times New Roman",serif; } 
.retracted-alert-text  { text-decoration: none; color: #000; }
.retracted-alert-text a, .retracted-alert-text a:visited { color: #3366CC; text-decoration: none;}
.abstract .retracted-alert-text a:hover { text-decoration: underline; color: #3366CC; }
.abstract .retracted-alert-text { font-family: "Source Sans Pro","Helvetica","Arial",sans-serif; 
    margin-bottom: 0; margin-top: 0; font-size: 1.3em; clear: both; }
.abstract .morecit { position: relative; margin-top: 1.5em; }
.abstract .morecit div { margin: 0; }
.collab h3, .afflist h3 { margin: .5em 0em; }
.abstract .morecit h3 {background-color: #f8f8f8; margin: 0; padding: 0.5em 0 0.14em; }
.abstract .morecit ul, .abstract .afflist ul { list-style-type: none; padding: 0; margin: 0 0 1.6em; }
.abstract .morecit ul li { margin-bottom: .1em; }
.abstract .morecit h3 a:hover {color: #777 !important; }
.abstract .morecit:first-child { margin-top: 3em; }
.abstract .morecit:last-child { margin-bottom: 2.6em; }
.supplemental .icons { margin-bottom: 1em; }
.supplemental .icons img{padding-bottom: 0.5em;}
.abstract .icons { text-align: left; margin-top: .5em; margin-top:5px; display: table; width:99%;}
.abstract .icons .floatLeft {float:left; min-width:45px;}
.abstract .icons .clearFloat{clear:both;}
.abstract .icons .vAlignCenter {display: table-cell; vertical-align: middle; width:100%}
.abstract .icons a { color: #000 !important;  text-decoration: none; }
.abstract .icons a:hover {text-decoration:underline; border-bottom: none; }
.abstract .icons a:visited { color: #606;}
.abstract .icons img { margin: .25em; }
.abstract .icons img:first-child { margin-left: 0; }
.abstract .label { position:absolute;left:-10000px;top:auto;width:1px;height:1px;overflow:hidden; }
.abstract .print-log { position:absolute;left:-10000px;top:auto;width:1px;height:1px;overflow:hidden; }
.abstract .print-log li { list-style-image: none; }
.abstract .other_lang{margin-bottom:0.5em;display:inline;padding-left: 0.5em;}
.abstract .other_lang .sel_lang{text-decoration:none;cursor:default; color:black; font-weight:bold;}
.abstract .abstr h3{display:inline;}
.abstract .abstr *[class^=abstr_]{margin-top:0.5em;}
#ncbi_share_pm{padding-top:0.5em;}
#ncbi_share_pm li button{margin-left:0em;}
div.morecit {
    border-top: 1px solid #DDDDDD;
}
div.morecit:hover {
    border-top: 1px solid #666666;
}
.abstract a.ui-ncbitoggler, .abstract a.ui-ncbitoggler-open {
    padding-left: 0;
}
.abstract .morecit h3 a:hover {
    color: #000000 !important;
}
div.morecit.open {
    border-bottom: 1px solid #FFFFFF;
    border-top: 1px solid #EEEEEE;
}
.abstract a.ui-ncbitoggler span.ui-icon, .abstract a.ui-ncbitoggler-open span.ui-icon {
    border: 1px solid #DDDDDD;
    border-bottom-left-radius: 3px;
    border-bottom-right-radius: 3px;
    left: auto;
    margin-top: -8px;
    padding: 5px;
    right: 0;
}
.abstract a.ui-ncbitoggler span.ui-icon.ui-icon-triangle-1-e {
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/4156578) repeat scroll -2px -2px transparent;
}
.abstract div.morecit:hover a.ui-ncbitoggler span.ui-icon-triangle-1-e {
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/4156578) repeat scroll -2px -2px transparent;
    border-color: #666666;
}
.abstract a.ui-ncbitoggler-open span.ui-icon.ui-icon-triangle-1-s {
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/4156578) repeat scroll -2px 28px transparent;
}
.abstract div.morecit:hover a.ui-ncbitoggler-open span.ui-icon-triangle-1-s {
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/4156578) repeat scroll -2px 28px transparent;
    border-color: #666666;
}
.abstract .afflist  a.ui-ncbitoggler span.ui-icon, .abstract .afflist  a.ui-ncbitoggler-open span.ui-icon,
.abstract .collab  a.ui-ncbitoggler span.ui-icon, .abstract .collab  a.ui-ncbitoggler-open span.ui-icon{
    border: none;
    left: auto;
    margin: 0;
    padding: 0;
     display: inline;
    left: 0;
    position: absolute;
    top:0px;
}
.abstract .afflist a.ui-ncbitoggler, .abstract .afflist  a.ui-ncbitoggler-open,
.abstract .collab a.ui-ncbitoggler, .abstract .collab  a.ui-ncbitoggler-open{
    padding-left: 16px;outline:none;
}
.abstract .afflist a.ui-ncbitoggler span.ui-icon.ui-icon-triangle-1-e,
.abstract .collab a.ui-ncbitoggler span.ui-icon.ui-icon-triangle-1-e{
    background-image: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/3974597);
    background-repeat: no-repeat;
    background-position: 0 -21px;
}
.abstract .afflist a.ui-ncbitoggler-open span.ui-icon.ui-icon-triangle-1-s,
.abstract .collab a.ui-ncbitoggler-open span.ui-icon.ui-icon-triangle-1-s{
    background-image: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/3974597);
    background-repeat: no-repeat;
    background-position: 0 0;
    top:3px;
}
a.ui-ncbitoggler-disabled {
    outline: none;
}
a.ui-ncbitoggler-disabled:active {
    outline: none;
}
.rprt .aff_inline_book{display:inline;}
.excerptTitle, .sectionsTitle{color:#985735; font-weight:bold;margin-bottom:0em; border:none;}
ul.sections {list-style:none;padding:0px;margin-top:0px;}
ul.sections ul {list-style:none;padding-left:0;}
ul.sections h4 {margin:0;}
.sections li {text-indent:-1.5em;padding-left:1.5em;}
.excerpt {margin-top:0em; border:none;}
.excerpt p{margin:0em;}
.sections a.ui-ncbitoggler, .sections a.ui-ncbitoggler-open { padding-left: .85em; }
.sections .ui-ncbitoggler-master-text { padding-left:0.3em; }
.sections a.ui-ncbitoggler:hover, .sections a.ui-ncbitoggler-open:hover { color: #777 !important; }
.book_icons{margin-top:5px;display: table;width:99%;overflow:auto;}
.book_icons .float_left {float:left; min-width:45px;}
.supplemental .book_icons {text-align:left; margin-bottom: 1em;}
.book_icons .v_align_center {display: table-cell; vertical-align: middle; width:100%; padding-left:5px;}
.book_icons  a { color: #14376C; text-decoration: none; display:block; }
.book_icons  a:active {border-bottom:none; }
.book_icons a:visited { color: #606;}
.book_icons .book_title_link {color:black;}
.book_icons a.book_title_link:visited {color:black;}
div.rprt span.rprtlinks span.in_clip, div.rprt span.rprtlinks a.rem_clip { margin-right: .5em; color: #D2692B; }
div.rprt_all { width:98% } 
.rprt_all #comments_panel { padding-right: 0; }
 #comment_who, #coments_panel_anchor { margin-right: 0.5em; } 
.ncbi_carousel {min-width:400px;}
.ncbi_carousel .nc_header span{font-weight:bold;color:#985735;}
.ncbi_carousel .nc_header a{margin: auto 0 auto 10px;}
.legend{font-size:1.2em;}
.legend .legend-citation{font-size:1em;margin-top:1em;}
.legend .legend-from{font-weight:bold;margin-top:2em;margin-bottom:1em;}
.legend .legend-from .legend-from-title{margin-right:10px;}
.social-buttons {
    display: inline-block;
    margin-bottom: 1em;
}
.social-buttons li + li { margin-left: 1em; }
.social-buttons button {
    background: none no-repeat scroll left top transparent;
    border: 0 none;
    display: inline-block;
    height: 16px;
    padding: 2px;
    text-indent: -999em;
    width: 16px;
    background-image: url("//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/3961366");
}
button[data-share="Facebook"] { background-position:0px 0px }
button[data-share="Twitter"] { background-position:0px -19px }
button[data-share="Google"] { background-position:0px -38px }
button[data-share="Reddit"] { background-position:0px -57px }
.social-buttons button:hover{ opacity: 1; }
.social-buttons * :focus { opacity: 1; }
.social-buttons button {opacity: 0.5;transition: opacity 0.2s linear 0s;}
#ncbi_share_box label, #ncbi_share_box input {font-size:1.2em;}
#ncbi_share_box  label{padding-right:5em;}
#ncbi_share_inp{width:200px;  border: 1px solid #EEEEEE; padding: 2px; border-radius:2px;}
#ncbi_share_inp:focus{outline:none;}
#ncbi_share_box .social-buttons button {opacity: 1;transition:none;}
.clearfix:before, .clearfix:after {
    content: "";
    display: block;
}
.send_to .hint { }
.display_settings, .send_to { margin: 0 0 1.1em 0; }
.display_settings li a { color: black; text-decoration: none; }
h4.content_header { margin-right: .2em;}
h4.send_to { float: right; _white-space: nowrap; }
.send_to .column_list { width: 20em; }
.disp_settings .column_list li { float: none; width: 9.5em; }
.sort .column_list li{width:13.5em;}
.format, .sort, .items { float: left; }
.format legend, .sort legend, .items legend, .send_to legend {font-weight:bold;margin: 2px 0 0 3px;}
.disp_settings { margin-left: 1em; _width:42em; }
div.results_settings{
    position:relative;  
    overflow:auto;width:100%;
}
ul.inline_list a{color: #2f4a8b;}
.results_settings .tgt_dark {
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/4016701) no-repeat scroll 100% 24.5% transparent;padding-right: 14px;
    font-weight: normal;
    text-decoration:none;
}
ul.inline_list{padding-right:100px;}
.one_setting .disp_settings { _width:21em; }
.two_settings .disp_settings { _width:31em; }
.send_to { _width: 9em;}
.disp_settings button.button_apply { margin: 11em .5em .5em .8em;  }
.send_to .submenu { border-top: 1px solid #ddd; padding: 1em; margin:0; }
.send_to .submenu ul { margin: 0; padding:0; list-style-type:none; }
.send_to .submenu ul li { margin-bottom: .4em; }
.send_to .submenu ul li label { display: block; }
.send_to .hint { margin: .5em 0; }
.email_alert { background-color: #fcc; display: block;}
.send_to .submenu ul.mybib_list li label { display: inline; position: relative; top: -2px; }
p#email_alert .hidden, p#email_captcha_alert .hidden { display: none; }
p#email_alert.email_alert, p #email_captcha_alert.email_alert { background-color: #fcc; display: block;  }
p#email_alert.email_success {background-color: #dfd;}
div#send_to_menu , div#send_to_menu2 { width:330px; z-index: 200; }
.send_to .column_list li { width: 9.5em; }
.send_to .mail ul li span label { display: inline;}
.content_header_new1{color:black;}
ul.inline_list a .label { font-weight: bold }
ul.inline_list a .separator { color: #666666; }
ul.inline_list a .value { color: #000; }
.results_settings .tgt_dark {
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/4016701) no-repeat scroll 100% 24.5% transparent;padding-right: 14px;
    font-weight: normal;
    text-decoration:none;
}
#sendto .tgt_dark { font-weight: bold; }
ul.inline_list{padding-right:100px;}
.results_settings.bottom { width: 50%; float: left; }
.results_settings.bottom .display_settings { padding-right: 10px; }
.portlet { border-top: .4em solid #97b0c8; padding-top: .461em; margin: .769em 0 2.154em 0; overflow: visible; line-height: 1.231em; zoom:1; }
.portlet h1, .portlet h2, .portlet h3, .portlet h4, .portlet h5, .portlet h6 {color: #985735; font-weight: bold; display: inline;  }
.portlet .whatsthis {color: #14376c; white-space: nowrap; margin-left: .3em;}
.portlet ul { margin: 0; padding: 0; }
.portlet ul li { list-style-type: none; margin-top: .461em; border-bottom: 1px dotted #CCC; padding-bottom: 0.4em; position: relative; overflow: visible; zoom:1;  }
.portlet .portlet_list li { border-bottom: 0; }
.portlet ul li a { font-weight: normal; color: #14376c; text-decoration: none; }
.portlet ul li a:hover,.portlet ul li a:active{border-bottom:0}
.portlet ul a { _display: block; _float: left; _clear: left; }
.portlet .seemore { display: block; text-align: right; color: #14376c; font-size: .923em; text-decoration: none; margin-top: .8em; }
.portlet .portlet_section_header { text-decoration: none; font-weight: bold; color: #000; border-bottom:0 } 
.portlet li.two_line { height: 2.461em; height\0: 2.361em; overflow: hidden; }
.portlet .two_line a { max-height: 2.453em; overflow: hidden; display: block; }
.portlet .long_info, .portlet p, .portlet .two_line .source, .portlet .one_line_source, .portlet_content .image .desc, .portlet ul li .desc a { color: #777;}
.portlet .two_line .source, .portlet .one_line_source { white-space: nowrap; position: absolute; right: 0; background-color: white; padding-left: .3em; }
.portlet .two_line .source { top: 1.231em; }
.portlet .two_line .tertiary { font-size: .769em; color: #777; position: absolute; right:0; background-color: white; padding: .1em 0 0 .3em; top: 1.6em; top\0: 1.5em; }
.portlet .portlet_content p { margin: .8em 0; }
.portlet .buttonwrap { float: left; position: relative; top: -.1em; overflow: visible; }
.portlet .invert { color: #fff; background-color: #14376c; padding: 0 .2em; }
.portlet .tertiary { color: #777; text-align: right; line-height: 1.4em; position: relative; top: .1em; }
.portlet_content { position: relative; margin: 0; }
.portlet_content textarea { margin: 0 0 .9em; }
.portlet_content img { margin: .3em 1.4em .7em 0;}
.portlet_content .image { display: block; overflow: auto; overflow:hidden\0; }
.portlet_content .image .img_link { float: left; }
.portlet_shutter { background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/32197) no-repeat scroll left top;  display: block; float: right; width: 15px; height: 15px; position: absolute; top: -.2em; margin-left: .6em; right: 0; }
.shutter_closed { background-position: left bottom; }
.portlet .related li { border-bottom: 0; }
.portlet .right { text-align: right; }
.ra_qry, .ra_rcd { padding-left: 2em; }
.ra_qry { background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/32182) no-repeat scroll 0 1px; }
.ra_rcd { background: transparent url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/32183) no-repeat scroll 0 1px; }
.sensor {border:1px solid #97B0C8;background-color:#FEFEFF;padding:0;margin:0 0 1em 0}
.sensor_inner {border:3px solid #D7E2EC;background-color:#FEFEFF;padding:0 1em 1em;margin:0}
.sensor .sensor_head { margin-bottom: 0; position: relative}
.sensor .sensor_head h3 { font-weight: normal; }
.sensor h3,.sensor h4,.sensor h5,.sensor h6{margin:.6923em 0 0}
.sensor .sensor_content{margin-bottom:1.1em}
.sensor p{margin:0}
.sensor .portlet_shutter { display: none; }
.no_p_margins{margin:0}
.portlet_head{margin-bottom:.461em;position: relative}
.portlet_title,.sensor_title{margin-right: 2em}
.portlet_title h3 { line-height: inherit; }
#ResultsHighlighter {  
    margin: .5em 0 1.0em;
    padding: .2em 0 .3em .4em;   
    background-color:#ffffdd;
    }
#ResultsHighlighter ul { 
    list-style-type: none; 
    padding: 0 1em; 
    margin: .4em 0 0 .3em;
}
li.highlight { margin: .2em 0em; }
 
li.highlight span.cit { 
    margin: .1em 0 .1em .5em; 
    color: #117;
    font-size: .9em;
} 
li.highlight span.cit abbr {
    border: none;
    font-style:italic;
}
#ResultsHighlighter h2, #CSResultsHeader h2 { 
    color: #444; 
    font-size: 1em;
    padding-bottom: .2em;
    margin: 0 auto;
}
#ResultsHighlighter span.all {
    float:right;
    clear:left;    
    padding-right:1em; 
}
#CSResultsHeader {  
    font-size: .9em; 
    margin: .5em 0 0 0;
    padding: .2em 0 .3em .4em;  
}
h3.result_count { display:inline; white-space:nowrap; margin: 0 0 2em;}
.result_sel { margin-left: 1em;white-space:nowrap;float: left;}
.clip_actions { margin-bottom: 1.3em; }
.clip_action { color: #D2692B;text-decoration: none; border-bottom: 1px dotted #D2692B; margin-left: 1em; white-space:nowrap; float:left;}
.sensor_inner .messages {margin-top:1em;}
.sensor_inner > p > .details{margin-left:3px;}
div.success_msg, div.warn_msg, div.error_msg { padding: .4em; margin: .5em; color: black; font-family: helvetica, arial, verdana, sans-serif; }
div.success_msg img, div.warn_msg img, div.error_msg img { position: relative; top: .15em; margin-left: .2em; }
div.success_msg { border: 1px solid #6c6; background-color: #cfc; }
div.warn_msg { border: 1px solid #e3d21c; background-color: #ffffef; }
div.error_msg { border: 1px solid #f88; background-color: #fdd; }
div.messagearea {
    margin:0;
    padding: 0;
    clear:both;
}
div.browsername {
    background-color: #FFF;
    padding-left: 0.5em;
    }
#messagearea.empty {
    border: none;
    clear: both;
}
div#messagearea ul.messages li.hi_warn { margin: 2.5em 0; }
ul.messages {
    font-family: arial, helvetica, sans-serif;
    margin: 0;
    padding: 0;
    list-style-type: none;
    list-style-image: none;
}
ul.messages li {
    margin: 0.22em 0 0.22em;
    padding: 0.25em;
    background: transparent no-repeat 0.5em 0.3em;
    position: relative;
}
ul.messages li .icon, ul.messages li.icon{ 
    background: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/3797312) no-repeat; 
    display: block; 
    margin-right: 4px;
    padding-left: 16px;
}
ul.messages li span.icon {
    background: #fff;
    padding-left: .5em;
    padding-top: .35em;
    margin-top: -.5em;
}
ul.messages li.success .icon, ul.messages li.success.icon {
    background-position: 0 0;
}
ul.messages li.warn .icon, ul.messages li.hi_warn .icon, ul.messages li.warn.icon, ul.messages li.hi_warn.icon {
    background-position: -17px 0;
}
ul.messages li.suggest .icon, ul.messages li.suggest.icon {
    background-position: -34px 0;
}
ul.messages li.info .icon, ul.messages li.info.icon {
    background-position: -51px 0;
}
ul.messages li.error .icon, ul.messages li.error.icon {
    background-position: -68px 0;
}
ul.messages li.hi_warn em.detail{
    font-weight: normal;
    font-style: normal;
    padding-left: 1.7em;
}
ul.messages li.hi_warn {
    font-weight: bold;
}
.success, .error, .warn, .info, .suggest, .hi_warn {
    background-image: url(//static.pubmed.gov/portal/portal3rc.fcgi/4188898/img/3797312);
    padding-left: 17px;
    background-repeat: no-repeat;
    background-color: transparent;
    margin-bottom:.5em
}
.success {
    background-position: 0 0;
}
.warn {
    background-position: -17px 0;
}
.hi_warn {
    background-position: -17px 0;
    font-weight: bold;
}
.suggest {
    background-position: -34px 0;
}
.info {
    background-position: -51px 0;
}
.error {
    background-position: -68px 0;
}
.searchdetails_term { width: 98%; }
.solr_searchdetails_term { background-color: white; color: black; }
#solr-searchdetails-all { border: 1px solid #ccc; width: 330px; }
#solr-searchdetails-all p { color: #303030; }
#search_details .seemore:focus { outline: none; }